![]() In 1858 he appears more acromegalic, but now with striking left eye displacement and slight proptosis (Fig. With a presumed pituitary adenoma this sign implies lateral growth from the sella turcica into the adjacent cavernous sinus. First, he persuasively demonstrates the systemic effects of GH excess (Fig. Pio Pico exhibits three manifestations of his tumor. Unregulated GH release most commonly arises from an anterior pituitary GH-secreting adenoma. Courtesy of the California History Section, California State Library, Sacramento, California Considering artistic rendition, the light reflections are symmetrical on each eye. Pico’s acromegalic features are apparent at age 46. ![]() Johnson, Pico’s niece and the former Estefana Alvarado. ![]() full-length oil-on-paper portrait of Pio Pico c.
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